A joint research collaboration between University of Hyderabad (UoH), National Institute of Nutrition (NIN) and IKP Knowledge Park over the last two years has culminated in the successful completion of a pre-clinical study on the anti-cancer drug ‘Temozolomide’ in animal models.
Temozolomide is the only drug approved for brain tumour. The stability of this otherwise potent chemotherapy is compromised due to degradation in storage and shelf handling, causing dark brown discoloration of the drug powder.
The research group of Prof. Ashwini Nangia at School of Chemistry, UoH developed stable pharmaceutical co-crystal of Temozolomide which overcomes the discoloration problem to give a stable, improved crystalline form of the drug.
Then in collaboration with the laboratory of Dr. Dinesh Kumar, Coordinator, Preclinical Toxicology at NIN, they tested the stable Temozolomide co-crystal with the reference drug in animal models to establish bioequivalence and bioavailability and drug transport, it was informed in a press release.
No comments:
Post a Comment